As the year comes to a close, we wanted to take a step back and reflect on what has defined peptide research over the past 12 months.
Using a combination of internal interest data, researcher enquiries, and broader global research trends, Bluewell Peptides Wrapped highlights the compounds, combinations, and questions that have shaped discussion across the peptide research space this year. This overview is provided strictly for research and educational purposes, with a focus on transparency, quality, and scientific curiosity.
Research Disclaimer
This article is provided for informational and educational purposes only. All compounds referenced are intended strictly for laboratory and scientific research. Bluewell Peptides does not provide medical advice, dosage guidance, or products for human or animal consumption.
The Most Researched Peptides of the Year
Retatrutide: One of the Most Researched Peptides of 2025
Retatrutide has experienced one of the most significant increases in research interest this year. It is a synthetic peptide analogue designed as a triple receptor agonist, interacting with GLP-1, GIP, and glucagon receptors. This multi-receptor profile sets it apart structurally and mechanistically from earlier single- or dual-receptor peptide analogues.
From a research perspective, retatrutide’s design allows scientists to explore multi-pathway receptor signalling, metabolic cross-talk, and peptide engineering within a single compound. As a result, it has become one of the most widely discussed and requested research peptides globally. At Bluewell Peptides, we have observed a clear and sustained rise in enquiries related to retatrutide, reflecting strong interest among academic and laboratory researchers.
BPC-157 and TB-500: Two of the Most Studied Research Peptides
BPC-157 and TB-500 remain among the most consistently researched peptides worldwide. While each compound is studied independently, they are frequently examined together in combined research models, leading to the informal “Wolverine Stack” nickname commonly used within research circles.
Scientifically, these peptides continue to attract attention due to their involvement in cell signalling pathways, tissue interaction mechanisms, and peptide stability characteristics. Their long-standing presence in research literature highlights sustained academic interest rather than short-term trends.
Peptide Blends: A Growing Trend in Peptide Research
Another defining trend this year has been the rise of multi-compound peptide research. Rather than isolating individual peptides, researchers are increasingly examining how compounds interact when studied together.
Blends involving GHK-Cu, BPC-157, TB-500, and KPV, are being explored for their complementary molecular characteristics. This reflects a broader shift toward investigating synergistic peptide behaviour, signalling interactions, and compound compatibility within controlled laboratory environments.
CJC-1295 (With DAC and Without DAC) and Ipamorelin
CJC-1295 continues to be a core focus within peptide research, with clear distinctions made between DAC (Drug Affinity Complex) and non-DAC variants.
- CJC-1295 with DAC is studied for its extended half-life, achieved through albumin binding.
- CJC-1295 without DAC has a shorter duration of action and is often researched in combination with other peptides.
Ipamorelin is frequently examined alongside non-DAC CJC-1295, particularly within studies exploring growth hormone signalling pathways. Understanding the structural and functional differences between DAC and non-DAC peptides has become an important research topic in its own right.
Melanotan II (MT-2)
Melanotan II continues to generate substantial research interest, particularly within studies focused on melanocortin receptor pathways. Its distinct structure and receptor affinity make it one of the most recognisable peptides in laboratory research, with consistent global demand.
GHK-Cu
GHK-Cu is one of the most extensively studied copper peptides, supported by decades of biochemical research. Its continued relevance is driven by interest in its binding behaviour, molecular stability, and signalling properties, making it a longstanding staple within peptide research discussions.
MOTS-c
MOTS-c has gained increasing attention as a mitochondria-derived peptide, distinguishing it from traditionally synthesised peptides. Researchers are actively examining how mitochondrial peptides differ in origin, signalling, and function, positioning MOTS-c as a key compound of interest in this emerging research area.
Tesamorelin
Tesamorelin remains highly relevant within research models focused on growth hormone releasing factors. Its defined structure and synthetic stability have contributed to continued academic and laboratory interest.
Selank and Semax: Russian Peptide Science
Selank and Semax originate from Russian peptide research, having been developed and studied within state-supported scientific institutes. These peptides are notable for their extensive documentation and their role in research examining neurological pathways and peptide signalling. Their unique scientific origin has helped sustain global research interest over time.
PT-141
PT-141 is structurally distinct from many other peptides and is studied primarily for its interaction with melanocortin receptors. Its mechanism of action differs significantly from MT-2, which has led to continued comparative research and academic interest.
NAD⁺ and NAD-Related Research
Although NAD⁺ is not a peptide, it remains closely associated with peptide research discussions due to its role in cellular energy metabolism and biochemical signalling pathways. Interest in NAD⁺ continues to grow alongside broader research into cellular regulation.
Most Asked Research Questions This Year
What Makes Retatrutide Unique Compared to Other Peptides?
Retatrutide’s ability to interact with three distinct receptor pathways allows researchers to investigate multi-pathway signalling within a single compound, making it structurally and functionally unique.
Why Are BPC-157 and TB-500 Frequently Studied Together?
Their complementary molecular characteristics and extensive research history make them well suited for combined laboratory investigation.
Why Are Lyophilised Peptides Preferred in Research?
Lyophilised peptides are widely favoured due to:
- Absence of fillers or unnecessary additives
- Guaranteed milligram accuracy
- Higher purity and stability
- Safer transport conditions
- Longer shelf life and easier storage
How Is Peptide Purity Verified?
Purity is typically assessed using HPLC testing, enabling accurate verification of peptide composition.
Why Are Strong Manufacturer Relationships and Two-Step Verification Important in Peptide Research?
Consistent peptide research starts long before third-party testing. Strong, transparent relationships with manufacturers allow access to raw material documentation at the powder stage, ensuring that purity and composition are verified across an entire batch, not just a single vial.
While independent third-party testing remains fundamental, many suppliers rely on testing one or two finished vials and apply those results broadly across the year. Without batch-level raw material data, this approach can overlook variability within larger production runs.
At Bluewell Peptides, verification begins at the raw powder level, supported by manufacturer documentation that confirms batch-wide purity and consistency. This is then followed by independent third-party re-verification through Axonis, creating a two-layer verification process. This dual approach helps ensure consistency, traceability, and reliability across every peptide vial within a batch, not just isolated samples.
Why Does Storage Matter for Peptide Stability?
Correct storage conditions help preserve molecular structure and prevent degradation, which is essential for reliable research outcomes.
Top Global Destinations for Peptide Research in 2025
United Kingdom
Search interest around UK peptides and peptides in the UK continues to grow, reflecting a strong domestic research environment.
Germany and the Wider EU
Germany remains a major scientific hub, with peptide research extending across multiple EU countries.
Dubai and Saudi Arabia
The Middle East has seen rapid growth in peptide research interest, supported by expanding research infrastructure.
Tokyo, Japan
Japan’s advanced biochemical research sector positions Tokyo as a key centre for peptide innovation.
United States
The USA continues to lead globally in peptide-related academic and laboratory research.
Austria
Austria has emerged as a smaller but increasingly notable centre for biochemical and peptide research.
Looking Ahead: The Future of Peptide Research
Across all regions, a clear trend is emerging: researchers are placing greater emphasis on quality, documentation, and scientific integrity. Peptides are increasingly studied as part of complex research models rather than in isolation, reflecting a maturing research landscape.
A Message to the Bluewell Community
Firstly, we want to express our appreciation to everyone within the Bluewell community. Working with dedicated researchers, customers, and clients throughout the year has been a genuine pleasure.
From everyone here at the Bluewell team, we wish you a Merry Christmas and a Happy New Year. We look forward to continuing to support high-quality, transparent peptide research in the year ahead.
